发明名称 |
5-(2,4-DIHYDROXY-5-ISOPROPYL-PHENYL)-4-(4-MORPHOLIN-4-YLMETHYL-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE MESYLATE, HYDRATES AND POLYMORPHS THEREOF, AND FORMULATIONS COMPRISING THESE FORMS |
摘要 |
The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the hydrochloride, tartrate, phosphate and hemi fumarate salt thereof; to crystalline forms of such salts; to polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide; to hydrates and polymorphs of the new salt forms mentioned above; to the use of the new salt forms mentioned above for the manufacture of a medicament for the treatment of a disorder mediated by Hsp90; to a method for treating a disorder mediated by Hsp90 using the new salt forms; to formulations comprising such salt forms, in particular aqueous solutions suitable for intravenous administration; and to amber glass containers being filled with such formulations.
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申请公布号 |
PT2131845(E) |
申请公布日期 |
2012.07.10 |
申请号 |
PT20080717228T |
申请日期 |
2008.02.28 |
申请人 |
NOVARTIS AG;VERNALIS (R&D) LTD |
发明人 |
MICHAEL MUTZ;CHRISTOPH KRELL;MARTIN JAMES DRYSDALE;BRIAN WILLIAM DYMOCK;HOLGER PETERSEN;WEIJIA ZHENG |
分类号 |
A61K31/5377;A61P35/00;C07D295/00 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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