发明名称 |
Liquid phase peptide synthesis of KL-4 pulmonary surfactant |
摘要 |
The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the α-carbon. |
申请公布号 |
US8217142(B2) |
申请公布日期 |
2012.07.10 |
申请号 |
US20080241171 |
申请日期 |
2008.09.30 |
申请人 |
ABDEL-MAGID AHMED F.;EGGMANN URS;MARYANOFF CYNTHIA ANNE;THALER ADRIAN;VILLANI FRANK J.;ORTHO PHARMACEUTICAL CORPORATION |
发明人 |
ABDEL-MAGID AHMED F.;EGGMANN URS;MARYANOFF CYNTHIA ANNE;THALER ADRIAN;VILLANI FRANK J. |
分类号 |
C07K1/06;A61K38/00;C07K1/02;C07K1/12;C07K5/083;C07K5/09;C07K14/785 |
主分类号 |
C07K1/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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