AMORPHOUS FORM OF ROXITHROMYCIN AND SYNTHESIS METHOD THEREOF

摘要

FIELD: chemistry. ^ SUBSTANCE: invention relates to organic chemistry and a method of producing an amorphous modification of roxithromycin (erythromycin-9-O-2-methoxy-ethoxy-methyl oxime) (formula I). According to the invention, the amorphous form of roxithromycin is obtained from its solutions in dimethyl formamide by evaporating the solvent at temperature not lower than 30C for not more than 36 hours. ^ EFFECT: cheap and easy method of producing an amorphous form of roxithromycin, having better solubility in water compared the crystalline form. ^ 1 dwg, 4 ex