| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to organic chemistry and specifically to a novel method of producing N-(1-adamantyl)acetamide, used to produce pharmaceutical preparations, involving reaction of 1-chloroadamantane with acetonitrile in the presence of water under the action of manganese-containing catalysts such as MnC2, MnBr2, Mn(acac)2, Mn2(CO)10 at temperature 130C for 2-3 hours, with molar ratio of reactants [Ad-Cl]:[CH3CN]:[H2O]:[Mn]=100:300-400:100:3. ^ EFFECT: ensuring complete conversion of 1-bromoadamantane and absence of by-products, ie, the only product is N-(1-adamantyl)acetamide. ^ 1 cl, 8 ex, 1 tbl |
