| 发明名称 |
Proteins with repetitive Bacterial-Ig-like (Big) domains present in Leptospira species |
| 摘要 |
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
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| 申请公布号 |
US8216594(B2) |
申请公布日期 |
2012.07.10 |
| 申请号 |
US201213359354 |
申请日期 |
2012.01.26 |
| 申请人 |
KO ALBERT I.;REIS MITERMAYER GALVAO;CRODA JULIO HENRIQUE ROSA;SIQUEIRA ISADORA CRISTINA;HAAKE DAVID A.;MATSUNAGA JAMES;RILEY LEE W.;BAROCCHI MICHELE;YOUNG TRACY ANN;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
KO ALBERT I.;REIS MITERMAYER GALVAO;CRODA JULIO HENRIQUE ROSA;SIQUEIRA ISADORA CRISTINA;HAAKE DAVID A.;MATSUNAGA JAMES;RILEY LEE W.;BAROCCHI MICHELE;YOUNG TRACY ANN |
| 分类号 |
A61K39/002;C07H21/04;C07K14/20;C12N1/21;C12Q1/68 |
主分类号 |
A61K39/002 |
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