| 发明名称 |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
| 摘要 |
The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
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| 申请公布号 |
US8217048(B2) |
申请公布日期 |
2012.07.10 |
| 申请号 |
US20100825237 |
申请日期 |
2010.06.28 |
| 申请人 |
PERNI ROBERT B.;COURT JOHN J.;BRITT SHAWN D.;PITLIK JANOS;VAN DRIE JOHN H.;VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
PERNI ROBERT B.;COURT JOHN J.;BRITT SHAWN D.;PITLIK JANOS;VAN DRIE JOHN H. |
| 分类号 |
A61K31/497;A61K31/4178;A61K31/4439;A61K31/501;A61K31/506;A61K31/517;A61K38/00;A61K38/05;A61K45/06;C07D241/24;C07D401/12;C07D401/14;C07D403/12;C07D403/14;C07K5/02;C07K5/06;C07K5/10;C07K7/02 |
主分类号 |
A61K31/497 |
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