发明名称 |
Combination therapy with IgA1 proteases |
摘要 |
The present invention discloses the use of bacterial IgA1 proteases to treat IgA1 deposition in tissue and organs. Bacterial IgA1 proteases specifically cleave IgA1 molecules and thus provide a means to specifically cleave and remove IgA1 depositions. Accordingly, therapeutic agents for the treatment of diseases characterized by IgA deposition are provided. In particular, therapeutic agents to treat IgA nephropathy, Dermatitis herpetiformis (DH), and Henoch-Schoenlein purpura (HS) are disclosed. |
申请公布号 |
US8216568(B2) |
申请公布日期 |
2012.07.10 |
申请号 |
US20080177125 |
申请日期 |
2008.07.21 |
申请人 |
PLAUT ANDREW G.;QIU JIAZHOU;TUFTS MEDICAL CENTER |
发明人 |
PLAUT ANDREW G.;QIU JIAZHOU |
分类号 |
A61K38/48;A61K;A61K6/00;A61K39/395;C12N9/00;C12N9/52;C12N9/64 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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