METHOD FOR SIMULATION OF BEHAVIORAL REACTIONS IN EXPERIMENTAL ANIMALS CHRONICALLY EXPOSED TO OPIOIDS

摘要

A method for simulation of behavioral reactions in experimental animals exposed to opioids includes administration of opioid in increasing doses. Opioid preparation Nalbuphine is administered to experimental animals (rats) intramuscularly daily once a day in one period of time for 98 days (14 weeks) with gradual – each 2 weeks – increase of doses, depending on animal weight for time of drug administration.