发明名称 |
Method of managing or treating pain |
摘要 |
A composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed. |
申请公布号 |
US8216604(B2) |
申请公布日期 |
2012.07.10 |
申请号 |
US20080047388 |
申请日期 |
2008.03.13 |
申请人 |
WATTS PETER JAMES;CASTILE JONATHAN DAVID;LAFFERTY WILLIAM COLUMBUS IAN;SMITH ALAN;ARCHIMEDES DEVELOPMENT LIMITED |
发明人 |
WATTS PETER JAMES;CASTILE JONATHAN DAVID;LAFFERTY WILLIAM COLUMBUS IAN;SMITH ALAN |
分类号 |
A61F13/00;A01N43/16;A01N43/40;A61K9/00;A61K31/35;A61K31/445;A61K31/4468;A61P25/04 |
主分类号 |
A61F13/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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