发明名称 |
BIODEGRADABLE PHASE SEPARATED SEGMENTED MULTI BLOCK CO-POLYMERS AND RELEASE OF BIOLOGICALLY ACTIVE POLYPEPTIDES |
摘要 |
The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in various biomedical applications as well as in pharmaceutical applications. Provided is a composition for the controlled release of at least one biologically active polypeptide to a host, comprising the at least one biologically active polypeptide encapsulated in a matrix comprising at least one phase separated, thermoplastic multi-block copolymer, the copolymer being characterized in that (i) it comprises at least two hydrolysable segments chosen from prepolymer (A) and prepolymer (B), prepolymer (A) having a Tg lower than 37°C and prepolymer (B) having a Tm of 40°C - 100°C under physiological conditions; (ii) the segments being linked by a multifunctional chain-extender; (iii) the segments are randomly distributed over the polymer chain; and (iv) prepolymer (A) contains a segment that is derived from a water soluble polymer. |
申请公布号 |
WO2012005594(A3) |
申请公布日期 |
2012.07.05 |
申请号 |
WO2011NL50502 |
申请日期 |
2011.07.08 |
申请人 |
INNOCORE TECHNOLOGIES B.V.;STEENDAM, ROB;FLIPSEN, THEODORUS ADRIANUS CORNELIUS;HIEMSTRA, CHRISTINE;ZUIDEMA, JOHAN |
发明人 |
STEENDAM, ROB;FLIPSEN, THEODORUS ADRIANUS CORNELIUS;HIEMSTRA, CHRISTINE;ZUIDEMA, JOHAN |
分类号 |
A61K9/16;A61K47/34;C08G81/02 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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