发明名称 |
COMBINATION OF VACCINATION AND INHIBITION OF MHC CLASS I RESTRICTED ANTIGEN PRESENTATION |
摘要 |
The present invention relates to a vaccine/inhibitor combination comprising as a vaccine at least one antigen and as an inhibitor at least one inhibitor of the major histocompatibility complex (MHC) class I restricted antigen presentation. The present invention furthermore relates to a method of vaccination of a mammal using the inventive vaccine/inhibitor combination. The present invention also provides kit of parts comprising the inventive vaccine/inhibitor combination, preferably in different parts of the kit, e.g. for prior, concurrent or subsequent administration of the different parts. Additionally the invention relates to a pharmaceutical composition comprising the inventive vaccine/inhibitor combination to further improve the immune response against tumour cells and infected cells having lost the capability of MHC class I restricted antigen presentation. |
申请公布号 |
WO2012089225(A1) |
申请公布日期 |
2012.07.05 |
申请号 |
WO2010EP07969 |
申请日期 |
2010.12.29 |
申请人 |
CUREVAC GMBH;LORENZ, CHRISTINA;FOTIN-MLECZEK, MARIOLA;KALLEN, KARL-JOSEF |
发明人 |
LORENZ, CHRISTINA;FOTIN-MLECZEK, MARIOLA;KALLEN, KARL-JOSEF |
分类号 |
A61K39/00;A61P31/12;A61P35/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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