发明名称 EXPRESSION VECTOR, METHOD FOR PRODUCING CARRIER USING SAME, AND USE OF SAME
摘要 Provided is a carrier which prevents decomposition of a medical agent and is capable of delivering the medical agent specifically to an in vivo target cell with excellent safety. A carrier-producing cell is obtained by introducing an expression vector, which comprises a nucleic acid sequence encoding a peptide that is capable of binding to a membrane protein of a target cell, into a membrane vesicle-producing cell. The carrier-producing cell is capable of producing a membrane vesicle which has, as a membrane peptide, a binding peptide that is capable of binding to a membrane protein of a target cell. Since the membrane vesicle is bound to the membrane protein of the target cell, a medical agent can be specifically administered to the target cell by having the membrane vesicle contain the medical agent.
申请公布号 WO2012091136(A1) 申请公布日期 2012.07.05
申请号 WO2011JP80513 申请日期 2011.12.28
申请人 TOKYO MEDICAL UNIVERSITY;KURODA MASAHIKO;OHNO SHINICHIRO;TAKANASHI MASAKATSU;UEDA SHINOBU;MIZUTANI TAKAYUKI;IKEDA NORIHIKO 发明人 KURODA MASAHIKO;OHNO SHINICHIRO;TAKANASHI MASAKATSU;UEDA SHINOBU;MIZUTANI TAKAYUKI;IKEDA NORIHIKO
分类号 C12N15/09;A61K31/7105;A61K31/713;A61K35/12;A61K35/14;A61K35/18;A61K35/28;A61K35/30;A61K35/48;A61K35/50;A61K47/42;A61K48/00;A61P35/00;C12N5/10 主分类号 C12N15/09
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