发明名称 |
EXPRESSION VECTOR, METHOD FOR PRODUCING CARRIER USING SAME, AND USE OF SAME |
摘要 |
Provided is a carrier which prevents decomposition of a medical agent and is capable of delivering the medical agent specifically to an in vivo target cell with excellent safety. A carrier-producing cell is obtained by introducing an expression vector, which comprises a nucleic acid sequence encoding a peptide that is capable of binding to a membrane protein of a target cell, into a membrane vesicle-producing cell. The carrier-producing cell is capable of producing a membrane vesicle which has, as a membrane peptide, a binding peptide that is capable of binding to a membrane protein of a target cell. Since the membrane vesicle is bound to the membrane protein of the target cell, a medical agent can be specifically administered to the target cell by having the membrane vesicle contain the medical agent. |
申请公布号 |
WO2012091136(A1) |
申请公布日期 |
2012.07.05 |
申请号 |
WO2011JP80513 |
申请日期 |
2011.12.28 |
申请人 |
TOKYO MEDICAL UNIVERSITY;KURODA MASAHIKO;OHNO SHINICHIRO;TAKANASHI MASAKATSU;UEDA SHINOBU;MIZUTANI TAKAYUKI;IKEDA NORIHIKO |
发明人 |
KURODA MASAHIKO;OHNO SHINICHIRO;TAKANASHI MASAKATSU;UEDA SHINOBU;MIZUTANI TAKAYUKI;IKEDA NORIHIKO |
分类号 |
C12N15/09;A61K31/7105;A61K31/713;A61K35/12;A61K35/14;A61K35/18;A61K35/28;A61K35/30;A61K35/48;A61K35/50;A61K47/42;A61K48/00;A61P35/00;C12N5/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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