PEPTIDE MOLECULES FOR TREATING MITOCHONDRIAL PATHOLOGIES
摘要
The present invention refers to peptide molecules consisting of a sequence of amino acids that is comprised in the C-terminal domain of a mitochondrial leucyl-tRNA synthetase for medical use, in particular for use in the treatment of mitochondrial diseases, and to a pharmaceutical compositions comprising the above peptide molecules and appropriate diluents and/or excipients. The present invention also refers to peptide molecules capable of suppressing the respiratory defect of human and/or yeast cells mutated in a mitochondrial gene coding for tRNA and to nucleotide sequences coding for the above peptides.
申请公布号
WO2012089570(A1)
申请公布日期
2012.07.05
申请号
WO2011EP73483
申请日期
2011.12.20
申请人
UNIVERSITA' DEGLI STUDI DI ROMA "LA SAPIENZA";DE LUCA, CRISTINA;FRANCISCI, SILVIA;FRONTALI, LAURA;MONTANARI, ARIANNA
发明人
DE LUCA, CRISTINA;FRANCISCI, SILVIA;FRONTALI, LAURA;MONTANARI, ARIANNA