| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a multicomponent dosage form, one component comprising tenofovir DF and, optionally, emtricitabine, and the other comprising at least efavirenz. <P>SOLUTION: In a new pharmaceutical product containing efavirenz, emtricitabine and tenofovir DF are provided as a multicomponent unitary oral dosage form, a component 1 comprising tenofovir DF (and, optionally, emtricitabine) and a component 2 comprising efavirenz, wherein the components 1 and 2 are in a stabilizing configuration. In preferred embodiments component 1 is made by dry granulation. A composition comprising tenofovir DF and a surfactant whereby the surfactant is in a stabilizing configuration with the tenofovir is provided. <P>COPYRIGHT: (C)2012,JPO&INPIT |
