POLYMALIC ACID-BASED NANOBIOPOLYMER COMPOSITIONS AND METHODS FOR TREATING CANCER

摘要

Nanobiopolymeric conjugates based on biodegradable, non-toxic and non- immunogenic poly (ß-L-malic acid) PMLA covalently linked to molecular modules that include morpholino antisense oligonucleotides (AONa), an siRNA or an antibody specific for an oncogenic protein in a cancer cell, and an antibody specific for a transferrin receptor protein, are efficient for treatment a cancer in a subject.