发明名称 |
SIRNA FOR INHIBITION OF HIF1A EXPRESSION AND ANTICANCER COMPOSITION CONTAINING THE SAME |
摘要 |
Disclosed are small interfering RNA (siRNA) that complementarily binds to a base sequence of Hif1a mRNA transcript, thereby inhibiting expression of Hif1a without inducing immune responses, and a use of the siRNA for prevention and/or treatment of cancer. Since Hif1a is commonly overexpressed in almost all cancer cells, the siRNA that complementarily binds to Hif1a-encoding mRNA may inhibit expression of Hif1a through RNA-mediated interference (RNAi), thereby inhibiting proliferation and metastasis of cancer cells, and thus, the siRNA may be useful as an anticancer agent.
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申请公布号 |
CA2823138(A1) |
申请公布日期 |
2012.07.05 |
申请号 |
CA20112823138 |
申请日期 |
2011.12.29 |
申请人 |
SAMYANG BIOPHARMACEUTICALS CORPORATION |
发明人 |
KIM, SUN-OK;KIM, SANG-HEE;CHO, EUN-AH;IN, CHANG-HOON |
分类号 |
C12N15/113;A61K31/7105;A61K48/00;A61P35/00 |
主分类号 |
C12N15/113 |
代理机构 |
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主权项 |
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地址 |
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