发明名称 |
A POLYPEPTIDE THAT BINDS ABERRANT CELLS AND INDUCES APOPTOSIS |
摘要 |
Described are proteinaceous molecules comprising at least a domain which comprises an amino acid sequence that specifically binds to an MHC-peptidecomplex on an aberrant cell, functionally connected with a substance that induces apoptosis in aberrant cells, but not in normal cells. These proteinaceous molecules are preferably used in selectively modulating biological processes. The provided proteinaceous molecules are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers. |
申请公布号 |
WO2012091563(A1) |
申请公布日期 |
2012.07.05 |
申请号 |
WO2011NL50891 |
申请日期 |
2011.12.22 |
申请人 |
APO-T B.V.;WILLEMSEN, RALPH ALEXANDER;RENES, JOHAN |
发明人 |
WILLEMSEN, RALPH ALEXANDER;RENES, JOHAN |
分类号 |
C07K16/28;A61P35/00;C07K16/30 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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