ANTI-HLA-E ANTIBODIES, THERAPEUTIC IMMUNOMODULATORY ANTIBODIES TO HUMAN HLA-E HEAVY CHAIN, USEFUL AS IVIG MIMETICS AND METHODS OF THEIR USE

摘要

Provided herein are compositions comprising antibodies immunoreactive to human leukocyte antigen E (HLA-E) and HLA Ia alleles, methods of their use, for example, as therapeutic IVIg mimetics, methods of their preparation and methods of their immunomodulatory benefits and applications. In particular embodiments provided herein are compositions and methods for treating an inflammatory condition or graft rejection.