发明名称 |
Neutralizing prolactin receptor antibodies and their therapeutic use |
摘要 |
The present invention is directed to the neutralizing prolactin receptor antibody 006- H08, as well as maturated forms thereof, and antigen-binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation. The antibodies of the invention block prolactin receptor-mediated signaling. |
申请公布号 |
AU2010330161(A1) |
申请公布日期 |
2012.07.05 |
申请号 |
AU20100330161 |
申请日期 |
2010.11.18 |
申请人 |
BAYER INTELLECTUAL PROPERTY GMBH |
发明人 |
OTTO, CHRISTIANE;WOLF, SIEGMUND;FREIBERG, CHRISTOPH;HARRENGA, AXEL;GREVEN, SIMONE;TRAUTWEIN, MARK;BRUDER, SANDRA;EICKER, ANDREA;WILMEN, ANDREAS |
分类号 |
C07K16/28;A61K39/395;A61P5/08;A61P35/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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