The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and/or the radiofluorination method of the invention on an automated radiosynthesis apparatus.
申请公布号
WO2012089594(A1)
申请公布日期
2012.07.05
申请号
WO2011EP73670
申请日期
2011.12.21
申请人
GE HEALTHCARE LIMITED;WICKSTROM, TORILD;SVADBERG, ANDERS;HJELSTUEN, OLE KRISTIAN;EVJE, DAG, M.;OCHSENFELD, LIANE
发明人
WICKSTROM, TORILD;SVADBERG, ANDERS;HJELSTUEN, OLE KRISTIAN;EVJE, DAG, M.;OCHSENFELD, LIANE