发明名称 |
POLYAMINE TRANSPORT INHIBITORS AS NOVEL THERAPEUTICS |
摘要 |
Novel polyamine transport inhibitors have been synthesized and demonstrated to block the uptake of native polyamines into human cancer cells. A combination therapy of the transport inhibitor and DFMO (a drug which blocks polyamine biosynthesis) provided synergistic activity against a metastatic human colon cancer cell line. The strategy uses polyamine depletion and polyamine metabolism to generate reactive oxygen species within cells as a novel way to treat cancers. This approach may be implemented for widespread use in the treatment of diseases which rely upon polyamine transport activity for proliferation. |
申请公布号 |
US2012172449(A1) |
申请公布日期 |
2012.07.05 |
申请号 |
US201013379191 |
申请日期 |
2010.06.21 |
申请人 |
PHANSTIEL OTTO;ARCHER JENNIFER J. |
发明人 |
PHANSTIEL OTTO;ARCHER JENNIFER J. |
分类号 |
A61K31/198;A61K31/137;A61K31/16;A61K31/166;A61P1/00;A61P1/04;A61P29/00;A61P35/00;C07C211/27;C07C237/22;C07C237/42;C12N5/09;C12Q1/02;G01N33/566 |
主分类号 |
A61K31/198 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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