DEUTERATED ACID ADDITION SALT OF SITALIPTIN

摘要

The deuterated acid addition salts of sitaliptin, which is 7-((3R)-3-amido-1-oxo-4-(2,4,5-trifluorophenyl)-butyl)-5,6,7,8-tetrahydro-3--trifluoromethyl-1,2,4-triazole(4,3-alpha) pyrazine, and the preparation method thereof are disclosed. The hydrate of deuterated acid addition salt of sitaliptin and its preparation method, the crystallographic form of deuterated phosphate anhydride, and the pharmaceutical composition containing the deuterated acid addition salts of sitaliptin and the use thereof for treating and/or preventing diabetes, adiposis, and hypertension are disclosed.