METHODS AND COMPOSITIONS FOR PREDICTING CHEMOTHERAPY SENSITIVITY

摘要

The instant application provides methods and related compositions pertaining to the identification of chemosensitivity in a patient. In a particular embodiment, the invention provides biomarkers for the identification of chemosensitivity in a breast cancer patient, wherein a reduced expression of an X-linked gene, such as XIST, in the breast cancer cells of the patient indicates that the breast cancer cells in the patient may be successfully treated with a platinum-based compound, such as cisplatin.