| 发明名称 |
NAPHTHYRIDINONE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS |
| 摘要 |
In one aspect, the invention relates to naphthyridinone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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| 申请公布号 |
US2012172391(A1) |
申请公布日期 |
2012.07.05 |
| 申请号 |
US201113340641 |
申请日期 |
2011.12.29 |
| 申请人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;STAUFFER SHAUN R.;MANKA JASON;JACOBS JON;ZHOU YA;BARTOLOME-NEBREDA JOSE MANUEL;MACDONALD GREGOR JAMES;CONDE-CEIDE SUSANA;JONES CARRIE K. |
发明人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;STAUFFER SHAUN R.;MANKA JASON;JACOBS JON;ZHOU YA;BARTOLOME-NEBREDA JOSE MANUEL;MACDONALD GREGOR JAMES;CONDE-CEIDE SUSANA;JONES CARRIE K. |
| 分类号 |
A61K31/4375;A61P3/04;A61P3/10;A61P25/00;A61P25/06;A61P25/08;A61P25/14;A61P25/18;A61P25/20;A61P25/22;A61P25/24;C07D471/04 |
主分类号 |
A61K31/4375 |
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