发明名称 |
ENGINEERED MICROPARTICLES FOR MACROMOLECULE DELIVERY |
摘要 |
A method for making a modified release composition, comprising: selecting a desired active agent and polymer matrix for formulating into a modified release composition; assessing degradation effect on release of the active agent from the composition including plotting polymer molecular weight (Mwr) at onset of active agent release vs. active agent molecular weight (MwA); predicting performance of multiple potential formulations for the composition based on the degradation assessment and average polymer matrix initial molecular weight (Mwo) to define a library of building blocks; determining the optimal ratio of the building blocks to satisfy a specified release profile; and making a modified release composition based on the optimal ratio determination.
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申请公布号 |
US2012172456(A1) |
申请公布日期 |
2012.07.05 |
申请号 |
US201013395245 |
申请日期 |
2010.09.10 |
申请人 |
LITTLE STEVEN R.;ROTHSTEIN SAM |
发明人 |
LITTLE STEVEN R.;ROTHSTEIN SAM |
分类号 |
A61K47/34 |
主分类号 |
A61K47/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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