发明名称 SYNTHESIS OF PROPIVERINE HYDROCHLORIDE
摘要 <p>The present invention provides a two step esterification process for the synthesis of Propiverine hydrochloride. In the synthetic scheme disclosed herein benzillic acid 1 is directly converted to di-propyl ester ether 7 from the known standard method. The intermediate thus obtained is reacted with N-Methyl 4-hydroxy piperidine in the presence of sodium t-butoxide at room temperature to get Propiverine base 5. This is then finally converted to Propiverine hydrochloride. The process of synthesis provides Propiverine hydrochloride in a very pure form (>99%) with a very good yield. The compound is very useful in treating urinary incontinence.</p>
申请公布号 EP2470504(A1) 申请公布日期 2012.07.04
申请号 EP20100847777 申请日期 2010.04.30
申请人 ANDAGAR RAMAKRISHNA, RAMESHA;ROY, ANJAN KUMAR 发明人 ANDAGAR RAMAKRISHNA, RAMESHA;ROY, ANJAN KUMAR
分类号 C07D211/46 主分类号 C07D211/46
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