发明名称 |
SCREENING METHOD |
摘要 |
<p>The present invention provides a novel variant androgen receptor (ARaiv) lacking ligand binding domain, a nucleic acid encoding the same and use thereof. That is, the present invention provides a method of screening for a substance for the prophylaxis or treatment of cancer, which includes contacting an ARaiv protein or ARaiv-producing cell with a test compound, measuring the activity of ARaiv (e.g., transcription regulating action of androgen responsive gene) or expression level thereof, and selecting a compound that suppresses the activity or expression level.</p> |
申请公布号 |
EP2471918(A1) |
申请公布日期 |
2012.07.04 |
申请号 |
EP20100820536 |
申请日期 |
2010.09.28 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
WATANABE, TATSUYA;NAKAYAMA, KAZUHIDE;NAKATA, DAISUKE;KUSAKA, MASAMI |
分类号 |
C12N15/00;A61K31/395;A61K45/00;A61P13/08;A61P35/00;A61P43/00;C07D227/087;C07K14/72;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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