| 摘要 |
<p>This invention describes new antifungal compounds that are aralkyl benzyl ethers of the formula (I):
wherein: Ar represents aryl, imidazolil, 1,2,4-triazolyl, benzimidazolil; R 1 , R 2 , R 4 and R 5 are independently hydrogen, halogen, C 1-6 alkyl; R 3 represents halogen, C 1-6 alkyl or O-R' where R'represents hydrogen or lower alkyl; R 6 represents aryl, substituted aryl, trifluoromethyl, trichloromethyl or O-R' where R' represents hydrogen or lower alkyl; being the substituents of the aryl a halogen or a radical tetrazolyl; n and m represent independently an integer between 0 and 5;
With the proviso that when Ar is imidazolil, R 3 is chlorine, R 6 is p -phenyl and R 1 , R 2 , R 4 and R 5 are hydrogen, n must be different from 2.
When n and m are not 0 and 1, R 3 or R 6 can be represented by substituents not necessarily equal. This invention also refers to their salts, solvates, prodrugs, esters, enantiomers and/or pharmaceutically acceptable diastereoisomers, or mixtures thereof, processes for the preparation of these compounds, intermediate compounds, pharmaceutical compositions comprising such compounds and/or derivatives, including those compounds and/or derivatives, as well as the uses and methods of these compounds and/or derivatives for the treatment and/or prevention of conditions and/or diseases caused by microorganisms such as fungi, bacteria and/or protozoa, for the inhibition of proliferation and/or survival of said microorganisms, for the treatment and/or prevention of colonization of microorganisms in an individual, and for the manufacture of a medicine.</p> |
