发明名称 |
Difluoromethyl-containing macrocyclic compounds as hepatitis C virus inhibitors |
摘要 |
The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. |
申请公布号 |
US8211891(B2) |
申请公布日期 |
2012.07.03 |
申请号 |
US20090433191 |
申请日期 |
2009.04.30 |
申请人 |
GAI YONGHUA;LIU DONG;MOORE JOEL D.;OR YAT SUN;WANG ZHE;ENANTA PHARMACEUTICALS, INC. |
发明人 |
GAI YONGHUA;LIU DONG;MOORE JOEL D.;OR YAT SUN;WANG ZHE |
分类号 |
C07D225/00;A61K31/495;A61P31/22;C07D295/00 |
主分类号 |
C07D225/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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