发明名称 |
Substituted arylsulfonylaminomethylphosphonic acid derivatives, their preparation and their use in the treatment of type I and II diabetes mellitus |
摘要 |
The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formula wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions. |
申请公布号 |
US8211923(B2) |
申请公布日期 |
2012.07.03 |
申请号 |
US20080669979 |
申请日期 |
2008.07.25 |
申请人 |
WAGNER HOLGER;LANGKOPF ELKE;ECKHARDT MATTHIAS;STREICHER RUEDIGER;SCHOELCH CORINNA;SCHULER-METZ ANNETTE;PAUTSCH ALEXANDER;BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
WAGNER HOLGER;LANGKOPF ELKE;ECKHARDT MATTHIAS;STREICHER RUEDIGER;SCHOELCH CORINNA;SCHULER-METZ ANNETTE;PAUTSCH ALEXANDER |
分类号 |
A61K31/404;A61K31/416;A61K31/4184;A61K31/423;A61K31/428;C07D209/04;C07D231/56;C07D235/04;C07D263/54;C07D277/62 |
主分类号 |
A61K31/404 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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