| 发明名称 |
A METHOD OF CRYSTALLIZATION OF (S)-N-METHYL-3-(1-NA PHTHYLOXY)-3- (2-THIENYL)PROPYLAMINE HYDROCHLORIDE (DULOXETINE). |
| 摘要 |
<p>(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride of formula (I) is crystallized in such a way that suspension of duloxetine in a mixture of an aprotic solvent and a protic solvent is stirred at an increased temperature under simultaneous reduction of the volume proportion of the protic solvent.</p> |
| 申请公布号 |
MX2012002621(A) |
申请公布日期 |
2012.07.03 |
| 申请号 |
MX20120002621 |
申请日期 |
2010.09.02 |
| 申请人 |
ZENTIVA, K.S.* |
发明人 |
RIDVAN, LUDEK;CINIBULK, JOSEF;GRUNWALDOVA, VERONIKA;BRUSOVA, HANA |
| 分类号 |
C07D333/16;C07D333/20 |
主分类号 |
C07D333/16 |
| 代理机构 |
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代理人 |
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| 主权项 |
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