HYDROGELS FOR WOUND OR ULCER DRESSINGS COMPRISING ENZYMES AND PREPARATION METHOD THEREOF

摘要

PURPOSE: A hydrogel containing enzyme is provided to prevent infection and to effectively enable wound healing. CONSTITUTION: A hydrogel of a three-layered structure comprises: a first layer containing biocompatible polymers, polyvalent alcohol, and glucose; a second layer containing the biocompatible polymers, polyvalent alcohol, glucoseoxidase(GOD); and a third layer containing the biocompatible polymers, polyvalent alcohol, and horseradish peroxidase. The first layer contains 1-15 wt% of polyvinyl pyrrolidone and 1-30 wt% of carageenan as a biocompatible polymer, 0.1-10 wt% of glycerin as the polyvalent alcohol, and 0.001-3 wt% of glucose as a substrate. The second layer contains 1-15 wt% of polyvinyl pyrrolidone and 1-30 wt% of carageenan as the biocompatible polymers, 0.1-10 weight of glycerin as the polyvalent alcohol, and 0.01-5 wt% of glucose oxidase as the enzyme.