发明名称 |
Bifunctional fusion protein with thrombolytic and anticoagulant activities and uses thereof |
摘要 |
This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.
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申请公布号 |
US8212003(B2) |
申请公布日期 |
2012.07.03 |
申请号 |
US20050526682 |
申请日期 |
2005.11.10 |
申请人 |
SHI BINGXING;WU ZUZE;YU AIPING;DONG CHUNNA;INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA |
发明人 |
SHI BINGXING;WU ZUZE;YU AIPING;DONG CHUNNA |
分类号 |
A61K38/48;A61K38/00;A61K38/16;A61P7/02;C07K14/00;C07K14/31;C07K14/47;C07K14/815;C07K19/00;C12N9/72;C12N15/12;C12N15/62 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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