Pyrrolidine derivatives as cyclic amp-specific phosphodiesterase inhibitors

摘要

There are described pyrrolidine compounds having the structural formula (II), where the meaning of substituents is disclosed in the description, that are potent and selective inhibitors of cyclic adenosine 3', 5'-monophosphate specific phosphodiesterase (cAMP specific PDE) especially PDE4. Further, there are described pharmaceutical preparations containing these compounds as well as use of the compounds as therapeutic preparations, for example in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators. Use of these compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.