发明名称 |
METHOD FOR PRODUCING MECHANICALLY ACTIVATED AMORPHOUS AND AMORPHOCRYSTALLINE COMPOUNDS OF GLUCONIC ACID CALCIUM SALT |
摘要 |
The invention relates to producing mechanically activated amorphous and amorphocrystalline compounds and compositions of gluconic acid calcium salt, to pharmaceutical products based thereon, to a method of the production and the use thereof for treating a wide spectrum of diseases caused by disorders of calcium metabolism in the organism. The inventive method consists in processing a crystalline gluconic acid calcium salt or the compounds thereof with excipients in grinding activator devices to achieve either the input specific energy value equal to or less than 10.4 kJ/g and an amorphocrystalline state, or the input specific energy value equal to or less than 10.5 kJ/g and an amorphous state. The obtained agents are assessed by means of x-ray diffraction, IR, NMR, ESR-spectroscopy, mass- or chromato-mass spectrometry and differential thermal analysis.; The mechanically activated amorphous and amorphocrystalline compounds and compositions are used as an active agent for producing pharmaceutical products for therapeutic, medical and preventive and hygienic purposes. The pharmaceutical preparations containing the therapeutically effective amount of active agent are perorally administered 1-6 times a day by doses of 0.2-6 g for at least one month. The invention can be used in the medical and food industries for producing biologically active agents, medicinal and preventive agents, medicinal preparations and for practical medicine for treating acute osseous, dental and other diseases caused by disorders of calcium metabolism in the organism. |
申请公布号 |
EA016596(B1) |
申请公布日期 |
2012.06.29 |
申请号 |
EA20100000222 |
申请日期 |
2008.06.30 |
申请人 |
KONYGIN GRIGORIY, NIKOLAEVICH;STRELKOV NIKOLAJ, SERGEEVICH;RYBIN DMITRIY, STANISLAVOVICH |
发明人 |
KONYGIN GRIGORIY, NIKOLAEVICH;STRELKOV NIKOLAJ, SERGEEVICH;RYBIN DMITRIY, STANISLAVOVICH;POZDEEV VIKTOR, VLADIMIROVICH;EELSUKOV EVGENY, PETROVICH;SHARAFUTDINOVA DILYARA, RASHIDOVNA;EFREMOV YURI, YAKOVLEVICH;PETUKHOV VLADIMIR, YURIEVICH;GUMAROV GABDRAUF, GABDRASHITOVICH |
分类号 |
C07C59/105;A61K31/191;A61P3/02;A61P3/14;C07C51/00;C07C51/41;C07C51/43 |
主分类号 |
C07C59/105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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