| 摘要 |
A composition comprising pharmacologically acceptable particulate material dispersed throughout a pharmacologically acceptable liquid carrier, the particulate material being maintained in the dispersed state by a steric stabiliser, wherein the steric stabiliser is a block copolymer having a number average molecular weight ranging from about 1,000 to about 3,000 comprising a steric stabilising polymeric segment, such as polyacrylamide, polyethylene oxide, polyhydroxyethylacrylate, poly N-isopropylacrylamide, polydimethylamino, ethylmethacrylate or polyvinyl pyrrolidone, and an anchoring polymeric segment, one or both of which are derived from one or more ethylenically unsaturated monomers that have been polymerised by a living polymerisation technique, wherein the steric stabilising polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the particulate material and secures the stabiliser to the particulate material. The composition is used for hyperthermia treatment and in a process of obtaining a diagnostic image. |
