| 发明名称 |
Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors |
| 摘要 |
The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders. |
| 申请公布号 |
US2012165519(A1) |
申请公布日期 |
2012.06.28 |
| 申请号 |
US201213413322 |
申请日期 |
2012.03.06 |
| 申请人 |
AHMED GULZAR;BRESLIN HENRY JOSEPH;BURKE JASON;CURRY MATTHEW A.;DIEBOLD JAMES L.;DORSEY BRUCE;DUGAN BENJAMIN J.;FENG DAMING;GINGRICH DIANE E.;GUO TAO;LEARN KEITH S.;LISKO JOSEPH G.;LIU RONG-QIANG;MESAROS EUGEN;MILKIEWICZ KAREN;OTT GREGORY R.;THEROFF JAY P.;THIEU THO V.;TRIPATHY RABINDRANATH;UNDERINER THEODORE L.;WELLS GREGORY J.;ZIFICSAK CRAIG A.;CEPHALON, INC. |
发明人 |
AHMED GULZAR;BRESLIN HENRY JOSEPH;BURKE JASON;CURRY MATTHEW A.;DIEBOLD JAMES L.;DORSEY BRUCE;DUGAN BENJAMIN J.;FENG DAMING;GINGRICH DIANE E.;GUO TAO;LEARN KEITH S.;LISKO JOSEPH G.;LIU RONG-QIANG;MESAROS EUGEN;MILKIEWICZ KAREN;OTT GREGORY R.;THEROFF JAY P.;THIEU THO V.;TRIPATHY RABINDRANATH;UNDERINER THEODORE L.;WELLS GREGORY J.;ZIFICSAK CRAIG A. |
| 分类号 |
C07D403/14;C07D401/14;C07D403/12;C07D405/12;C07D405/14;C07D409/14;C07D413/12;C07D413/14;C07D417/14;C07D498/04 |
主分类号 |
C07D403/14 |
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