| 摘要 |
Described herein is an implantable medical device that has one or more surfaces that include one or more shallow recesses configured to receive a drug delivery composition comprising a polymeric matrix and one or more biologically active agents. In one embodiment, one or more surfaces comprise a frictional surface. In a more particular embodiment, the implantable medical device comprises a stem configured for insertion into a bone of a patient, wherein the stem comprises one or more surfaces that include one or more shallow recesses configured to receive a drug delivery composition comprising a matrix and one or more biologically active agents. The drug delivery composition can be a durable drug delivery matrix, a biodegradable drug delivery matrix, or a combination thereof. Methods of making such an implant are also provided. |
