HIV inhibiting bicyclic pyrimidine derivatives

摘要

HIV replication inhibitors of formula (I) -oxides, pharmaceutically acceptable addition salts, quaternary amines or stereoisomeric forms thereof, wherein -a=a-a=a- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, -N=CH- CH=N-, -N=N-CH=CH-; -b=b-b=b- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, -N=CH-CH=N-, -N=N-CH=CH-; n and m is 0, 1, 2, 3 and in certain cases also 4; R is hydrogen; aryl; formyl; Calkylcarbonyl; optionally substituted Calkyl; Calkyloxycarbonyl; R is OH; halo; optionally substituted Calkyl, Calkenyl or Calkynyl; substituted carbonyl; carboxyl; CN; nitro; amino; substituted amino; polyhalomethyl; polyhalomethylthio; -S(=O)R ; C(=NH)R; R is CN; amino; substituted amino; optionally substituted Calkyl; halo; optionally substituted Calkyloxy; substituted carbonyl; -CH=N-NH-C(=O)-R; optionally substituted CalkyloxyCalkyl; substituted Calkenyl or Calkynyl; -C(=N-O-R)-C alkyl; R or -X-R; R is CN; amino; Calkyl; halo; optionally substituted Calkyloxy; substituted carbonyl; -CH=N-NH-C(=O)-R; substituted Calkyl; optionally substituted CalkyloxyCalkyl; substituted Calkenyl or Calkynyl; -C(=N-O-R)-C alkyl; R; -X-R; R is halo; OH; optionally substituted Calkyl, Calkenyl or Calkynyl; Ccycloalkyl; Calkyloxy; CN; nitro; polyhaloCalkyl; polyhaloCalkyloxy; substituted carbonyl; formyl; amino; mono- or di(Calkyl)amino or R; -A-B- is -CR=N-, -N=N-, -CH-CH-, -CS-NH-, -CO-NH-, -CH=CH-; pharmaceutical compositions comprising these; methods for the preparation of these compounds and compositions; the use of these compounds for the prevention or the treatment of HIV infection.