发明名称 |
DPI Formulation Containing Sulfoalkyl Ether Cyclodextrin |
摘要 |
An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.
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申请公布号 |
US2012164184(A1) |
申请公布日期 |
2012.06.28 |
申请号 |
US201113335780 |
申请日期 |
2011.12.22 |
申请人 |
PIPKIN JAMES D.;MOSHER GEROLD L.;HECKER DOUGLAS B.;CYDEX PHARMACEUTICALS, INC. |
发明人 |
PIPKIN JAMES D.;MOSHER GEROLD L.;HECKER DOUGLAS B. |
分类号 |
A61K9/16;A61K9/00;A61K47/40;A61P11/00;A61P29/00;B32B5/16 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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