METHOD AND SYSTEM FOR REVERSAL OF INTERACTIONS BETWEEN HYDROPHOBICALLY MODIFIED BIOPOLYMERS AND VESICLES OR CELL MEMBRANES
摘要
A method for reversing gelation of hydrophobically modified biopolymer attached to vesicle or cell membranes. The gelation of hydrophobically modified biopolymer attached to vesicles or cell membranes is reversed by application of a supramolecule, such as cyclodextrin, to the gelled composition. The supramolecule disrupts the interactions between the hydrophobically modified biopolymer and the vesicle or cell membrane, without affecting the structure of the membrane or the hydrophobically modified polymer to which the hydrophobic substituents are attached. A kit for treating wounds that includes a hydrophobically modified biopolymer and a supramolecule. The hydrophobically modified biopolymer is used to stop bleeding and the supramolecule is used to remove the hydrophobically modified biopolymer.
申请公布号
WO2012021877(A3)
申请公布日期
2012.06.28
申请号
WO2011US47694
申请日期
2011.08.13
申请人
UNIVERSITY OF MARYLAND, COLLEGE PARK;DOWLING, MATTHEW;KUMAR, RAKESH;RAGHAVAN, SRINIVASA, R.
发明人
DOWLING, MATTHEW;KUMAR, RAKESH;RAGHAVAN, SRINIVASA, R.