METHOD FOR PREPARING COMPREHENSIVE ANTI-SURFACE ANTIBODY USING MICROORGANISM IMMOBILIZED AS ANTIGEN WITH PROTEIN CROSSLINKING AND IMMOBILIZATION REAGENT

摘要

A method for preparing comprehensive antibodies against whole proteins that are expressed on the surface of a microorganism and the comprehensive antibodies obtained by the method are provided. The method for preparing comprehensive antibodies against whole proteins that are expressed on the surface of a microorganism comprises: (a) treating a microorganism with a protein crosslinking and immobilization reagent and thus immobilizing proteins expressed on the surface of the microorganism via intramolecular crosslinking; (b) administering the microorganism as an immunogen immobilized using the protein crosslinking and immobilization reagent to an animal; and (c) obtaining antibodies from the animal.