发明名称 |
METHODS OF INHIBITING THE ACTIVITY OF HSP90 AND/OR ARYL HYDROCARBON RECEPTOR |
摘要 |
The present invention relates to a method of screening compounds for binding to hsp90 by exposing a compound to hsp90 or a polypeptide fragment thereof containing amino acid residues 538-728 of the full length protein and determining whether the compound binds to hsp90 of the polypeptide fragment thereof. Also disclosed is a method of screening compounds for inhibition of hsp90 activity. The present invention further relates to a method of screening compounds as a cancer therapeutic and a method of treating cancerous conditions. Also disclosed is a method of inhibiting transcription-inducing activity of an aryl hydrocarbon receptor in a cell and a method of modifying expression of a gene that is activated by an aryl hydrocarbon receptor. |
申请公布号 |
US2012165403(A1) |
申请公布日期 |
2012.06.28 |
申请号 |
US201113316092 |
申请日期 |
2011.12.09 |
申请人 |
GASIEWICZ THOMAS A.;PALERMO CHRISTINE;UNIVERSITY OF ROCHESTER |
发明人 |
GASIEWICZ THOMAS A.;PALERMO CHRISTINE |
分类号 |
A61K31/353;A61P35/00;C12N5/09 |
主分类号 |
A61K31/353 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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