发明名称 |
NOVEL MULTICOMPONENT CRYSTALS MADE OF ([2-AMINO-6-(4-FLUORO-BENZYLAMINO)-PYRIDIN-3-YL]-CARBAMIC ACID ETHYL ESTER AND 2-[2-[(2,6-DICHLORPHENYL)-AMINO]-PHENYL] ACETIC ACID |
摘要 |
The invention relates to novel multicomponent crystals, to the production thereof, and to the use thereof for treating pain conditions, in particular of unclear genesis, by means of a simultaneous effect on pains which are caused by muscle tension or degenerative joint diseases as well as on pains that are based on inflammatory processes. The novel multicomponent crystals contain ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester (flupirtine) and 2-[2-[(2,6-dichlorphenyl)-amino]-phenyl]-acetic acid (diclofenac) as the sole active ingredient combination and can be produced by dissolving the two components in a molar ratio of 1.0 : 0.9 to 1.0 : 1.1 in an inert organic solvent and subsequently crystallizing the complex compound.
|
申请公布号 |
CA2821311(A1) |
申请公布日期 |
2012.06.28 |
申请号 |
CA20112821311 |
申请日期 |
2011.12.20 |
申请人 |
AWD.PHARMA GMBH & CO. KG |
发明人 |
HOOCK, CHRISTOPH MARTIN;QADAN, ASAL;TERHAAG, BERND |
分类号 |
C07D213/75;A61K31/44;A61P25/04;A61P29/00;C07C229/42 |
主分类号 |
C07D213/75 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|