发明名称 NOVEL MULTICOMPONENT CRYSTALS MADE OF ([2-AMINO-6-(4-FLUORO-BENZYLAMINO)-PYRIDIN-3-YL]-CARBAMIC ACID ETHYL ESTER AND 2-[2-[(2,6-DICHLORPHENYL)-AMINO]-PHENYL] ACETIC ACID
摘要 The invention relates to novel multicomponent crystals, to the production thereof, and to the use thereof for treating pain conditions, in particular of unclear genesis, by means of a simultaneous effect on pains which are caused by muscle tension or degenerative joint diseases as well as on pains that are based on inflammatory processes. The novel multicomponent crystals contain ([2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl]-carbamic acid ethyl ester (flupirtine) and 2-[2-[(2,6-dichlorphenyl)-amino]-phenyl]-acetic acid (diclofenac) as the sole active ingredient combination and can be produced by dissolving the two components in a molar ratio of 1.0 : 0.9 to 1.0 : 1.1 in an inert organic solvent and subsequently crystallizing the complex compound.
申请公布号 CA2821311(A1) 申请公布日期 2012.06.28
申请号 CA20112821311 申请日期 2011.12.20
申请人 AWD.PHARMA GMBH & CO. KG 发明人 HOOCK, CHRISTOPH MARTIN;QADAN, ASAL;TERHAAG, BERND
分类号 C07D213/75;A61K31/44;A61P25/04;A61P29/00;C07C229/42 主分类号 C07D213/75
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