CHELATED COPPER FOR USE IN THE PREPARATION OF CONJUGATED OLIGONUCLEOTIDES

摘要

In one embodiment, the invention features a process for preparing ligand conjugated oligonucleotides comprising a step of contacting a nucleoside or oligonucleotide containing an alkyne moiety with ligand containing an azide moiety in the presence of a solid supported copper catalyst of formula A, B, C or D.