1-BENZYL-PYRIMIDINE-2,4-DIONE DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS , PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND USE THEREOF IN THE PREPARATION OF MEDICAMENTS

摘要

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising Formula I: wherein M is N or CR4; Q<1> and Q<2> are each independently selected from the group consisting of CO, SO, SO2, and C=NR9; and each R1, R2, R3, R4 and R9 are as defined herein.