A METHOD OF DIFFERENTIATING ONCOGENIC CHANGES OF THE THYROID, A KIT TO EMBODY THE METHOD AND THE USE OF METALLOTHIONEIN (MT) FOR DIFFERENTIATING ONCOGENIC CHANGES OF THE THYROID

摘要

A method of differentiating oncogenic changes of the thyroid encompassing follicular adenoma and follicular cancer, characterised in that in a sample of oncogenic tissue from a patient the expression of the metallothionein (MT) potein is evaluated using immunochistochemical methods using monoclonal anti-MT antibodies, the degree of intensity of the expression of metallothionein is evaluated under a light microscope using the semiquantitative IRS method according to Remmele, wherein if the degree of intensity of the expression of metallothionein is equal to or greater than 8 on the semiquantitative IRS scale then the presence of follicular cancer is indicated.