发明名称 |
COMPOSITIONS AND METHODS RELATING TO NON-HUMAN ANIMALS MODIFIED TO PROMOTE PRODUCTION OF SELECTED GAMETES |
摘要 |
Methods and compositions for producing selected non-human mammalian germ cells and gametes and for making non-human animals using the produced germ cells and gametes are provided by the present invention. Methods of generating a non-human embryo and/or animal derived from donor stem cells, methods of generating chimeric non-human animals having substantially all gametes and/or germ cells derived from the donor stem cells, methods of producing a non-human host embryo lacking functional endogenous germ cells and non-human host embryos incapable of developing endogenous gametes of the present invention are described herein. |
申请公布号 |
US2012167242(A1) |
申请公布日期 |
2012.06.28 |
申请号 |
US201113337892 |
申请日期 |
2011.12.27 |
申请人 |
WILES MICHAEL V.;TAFT ROBERT;THE JACKSON LABORATORY |
发明人 |
WILES MICHAEL V.;TAFT ROBERT |
分类号 |
C12N15/877;C12N5/10 |
主分类号 |
C12N15/877 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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