发明名称 |
ANTI-FOLATE RECEPTOR ALPHA ANTIBODY GLYCOFORMS |
摘要 |
The invention provides anti-FRA antibodies with novel N-linked neutral glycan profiles in that the relative amounts of one or more neutral glycans are increased or decreased compared to anti-FRA antibodies produced under reference cell culture conditions. The invention further provides anti-FRA antibodies with altered binding to FRA, altered antibody-dependent cellular cytotoxicity (ADCC) and/or altered rate and/or efficiency of internalization in a cell expressing FRA. In related aspects, the invention provides cell cultures comprising an anti-FRA antibody of the invention, a cell isolated from such a culture, kits and compositions comprising an anti-FRA antibody of the invention, methods of producing an anti-FRA antibody of the invention and diagnostic and therapeutic uses of an anti-FRA antibody of the invention. |
申请公布号 |
US2012164137(A1) |
申请公布日期 |
2012.06.28 |
申请号 |
US201113277161 |
申请日期 |
2011.10.19 |
申请人 |
SASS PHILIP M.;NICOLAIDES NICHOLAS;GRASSO LUIGI;ROUTHIER ERIC;GU WEI;YOUNG JASON;YAO JUN;MORPHOTEK, INC. |
发明人 |
SASS PHILIP M.;NICOLAIDES NICHOLAS;GRASSO LUIGI;ROUTHIER ERIC;GU WEI;YOUNG JASON;YAO JUN |
分类号 |
A61K39/395;A61P35/00;A61P35/02;C07K16/28;C12N5/10;C12P21/08;G01N33/566;G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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