| 摘要 |
The invention comprises compounds of the formula: <FORM:0959264/C2/1> (wherein R is alkyl or alkenyl of at most 4 carbon atoms, R1 is methyl or ethyl, R11 is hydrogen, methyl or ethyl, R111 is hydrogen or alkyl of at most 4 carbon atoms and R1111 is alkyl or alkoxy of at most 4 carbon atoms, or R111 and R1111 together with the nitrogen atom can form a saturated hererocyclic radical which may contain a further hetero atom) and their preparation by (1) reacting a compound of the formula: <FORM:0959264/C2/2> (wherein X is a reactive group such as a halogen atom or an alkyl- or aryl-sulphonyl group) with the appropriate 3-alkoxy-4-hydroxy-benzoic acid ester; or (2) reacting a 3-alkoxy-4-(a -carboxyalkoxy)-benzoic acid ester or a reactive functional derivative thereof with the appropriate amine NHR111R1111 or a reactive derivative thereof; or (3) reacting an acid of the formula: <FORM:0959264/C2/3> or a reactive derivative thereof with the appropriate alcohol ROH or a reactive ester thereof such as a halide. Examples are given. Chloroacetic acid-N-ethoxy-N-ethylamide is prepared from a -chloroacetyl chloride and N,O-diethyl-hydroxylamine. 3-Methoxy-4-carbomethoxy-benzoic acid n-propyl ester is prepared from vanillic acid n-propyl ester and sodium chloroacetate. 3-Methoxy-4-(N,N-diethylcarbamidomethoxy)-benzoic acid is prepared by saponification of the methyl ester.
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